Jones was born in Naples, Texas, United States, to sharecropping parents, and played guitar whilst young but switched to piano after a move to Dallas. He often played guitar on one or two songs on his albums and at live performances. In 1936 he relocated to Chicago, where he recorded between 1937 and 1941 on Vocalion, Bluebird, and OKeh. Among his best-known tunes from these recordings were the hit "Lonesome Bedroom Blues" and the song "Tin Pan Alley". His "Decoration Blues" though unissued at the time, was recorded by Sonny Boy Williamson I in 1938. World War II interrupted his recording career, which he did not resume until 1953, when a single of his, "Wrong Blues"/"Cool Playing Blues", was released on Parrot, featuring L. C. McKinley on guitar.
Jones's first full-length album appeared in 1960 on Bluesville, by which time he had become a noted performer on the Chicago folk music scene. A solo album was released in 1962, by which time Jones had moved to Europe. He lived there and in Morocco for the rest of his life. He made further albums in the UK, including one in 1968 that featured Alexis Korner on guitar.
One of Jones' songs, "Highway 51", was included on Bob Dylan's 1962 debut album, Bob Dylan.
Volume 1
01. Decoration Day Blues
02. Blues And Trouble (take 1)
03. Blues And Trouble (take 2)
04. Lonesome Bedroom Blues
05. You Got Good Business
06. Drinking And Thinking Blues
07. Shoolmate Blues
08. Bad Avenue Blues
09. Good Old Easy Street
10. Blues And Trouble(take 3)
11. Little Jivin' Woman
12. My Baby's Getting Buggish
13. Down In The Slums
14. Let Me Be Your Playmante
15. Highway 51 Blues
16. It's A Low Down Dirty Shame
17. Yours All Alone
18. Palace Blues(take 2)
19. Reckless Life Blues
20. Bull And Cow Blues
21. Love Season Blues
22. Palace Blues(take 4)
23. Lonesome Bedroom Blues No. 2
Volume 2
01. Loving blues
02. Good whiskey
03. Pocket book blues
04. Black gypsy blues
05. Alley bound blues
06. Who you're hunchin'
07. Mistakes in life
08. Hot dog man
09. I'm with you again
10. I'm losing my mind over you
11. Reefer hound blues
12. War broke out in hell
13. Little girl, little girl
14. Night life blues
15. Hattie mae blues
16. Blues in the alley
17. Down in the gutter
18. Blues in the basement
19. Love I'm without a shelter
20. Sad, lonely and crying blues
21. I'm fallin' for you baby
22. Roll me mama
23. When you leave me honey
24. He's just my size
25. Hop head blues
Volume 3
01. What Evil Have I Done
02. It's A Hard Way To Travel
03. I'm In The Mood For You
04. Who You Lovin'
05. I Like The Way You Do
06. My Baby's Blues
07. Private Talk Blues
08. Blue And Lonesome
09. Bosom Friend Blues
10. Heavy Hip Mama
11. Solid Jive
12. Love In A Loving Way
13. Gold Digger Blues
14. Sugar Bowl Blues
15. Treat Me Like I Treat You
16. Heart Breaking Blues
17. Moonlight Lover Blues
18. Cradle Rockin Blues
19. Day And Night Blues
20. Love Land Blues
21. Down Town Blues
22. Blue Memories
Volume 4
01. Low Down Worried Blues
02. Mean Old Blues
03. Love Valley Blues
04. Dream Land Blues
05. Too Many Blues
06. Worryin' Away My Heart For You
07. It's A Solid Sender
08. Ity Bitty Jitter Bug
09. Tin Pan Alley
10. Glamour And Glory Blues
11. My Baby Says She Loves Me
12. Bed Side Blues
13. Don't Leave Me Baby
14. Her Love Will Get It
15. Wrong Blues
16. Cool Playing Blues
17. Flamin' Blues
18. Upside Down Blues
19. No Good Guy, Part 2
20. Absent Freight Train Blues
21. South Land Blues